Publication | Closed Access
Heteronemin, a marine sponge terpenoid, targets TDP-43, a key factor in several neurodegenerative disorders
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Citations
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References
2013
Year
Tdp-43 Aggregation StateMolecular BiologyNeurochemical BiomarkersTdp-43-cognate Nucleic AcidsChemical ProteomicsSeveral Neurodegenerative DisordersDegenerative PathologyNeurologyNeuropathologyProteomicsNeurochemistryBiochemistryMedicineNeuropharmacologyNeurodegenerationChromatinNeurodegenerative DiseasesNatural SciencesDegenerative DiseaseMarine Sponge TerpenoidNeuroscienceMolecular NeurobiologyMolecular SubstrateTargets Tdp-43
Trans-activation response DNA-binding protein of 43 kDa (TDP-43), a key factor in several neurodegenerative conditions, was discovered as a novel target of heteronemin by chemical proteomics. Combining bio-physical orthogonal approaches with biological analysis, heteronemin was found to influence the binding of TDP-43-cognate nucleic acids and to modulate the TDP-43 aggregation state and its cellular localization.
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