Natural Polymer Hydrophilic Matrix: Influencing Drug Release Factors

Abstract

In porous hydrophilic polymeric systems, two phenomena control the release of drugs: the water uptake and polymer swelling.Directly compressed hydrophilic matrices were prepared with scleroglucan as gelling agent. A principal components analysis enables the authors to study the correlation between the above phenomena and the dissolution behavior in order to interpret the effect of polymer concentration, excipient solubility and compression force on the drug release.