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Zolpidem Arousing Effect In Persistent Vegetative State Patients: Autonomic, Eeg And Behavioral Assessment

DOI

47

Citations

0

References

2013

Year

Calixto Machado, Mario Estévez, Rafael Rodríguez‐Rojas, Jesús Pérez-Nellar, Mauricio Chinchilla, Philip A. DeFina, Gerry Leisman, Frederick Robert Carrick, Robert Melillo, Adam Schiavi,
Current Pharmaceutical Design

Abstract

We demonstrated time-related arousing signs after Zolpidem intake. We discussed possible mechanisms to explain these patho-physiological findings regarding EEG cortical activation and an autonomic vagolytic drug effect. As this autonomic imbalance might induce cardiocirculatory complications, which we didn't find in any of our patients, we suggest developing future trials under control of physiological indices by bedside monitoring. However, considering that this arousing Zolpidem effect might be certainly related to brain function improvement, it should be particularly considered for the development of new neuro-rehabilitation programs in PVS cases. According to the literature review, we claim that this is the first report about the vagolitic effect of Zolpidem in PVS cases.