<i>IGH@</i> Translocations, <i>CRLF2</i> Deregulation, and Microdeletions in Adolescents and Adults With Acute Lymphoblastic Leukemia

Abstract

CRLF2-d and IGH@-t represent distinct subtypes of adolescent and adult ALL. Deletions of key B-cell differentiation and cell cycle control genes are highly prevalent but vary in frequency by cytogenetic subgroup. CRLF2-d, IGH@-t, and IKZF1 deletions are associated with poor outcome in adolescent and adult ALL.