Highly Diastereo‐ and Enantioselective Mukaiyama Aldol Reactions Catalyzed by Hydrogen Bonding

Abstract

Enzyme lite: Like a minimalist enzyme, a simple chiral alcohol of the taddol family, 1, catalyzes Mukaiyama aldol reactions between silyl enolates of amides and aldehydes to afford products with high diastereo- and enantioselectivities (see scheme; TBS=tert-butyldimethylsilyl). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z601638_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.