Chromatic and Luminance Contrast Sensitivities in Asymptomatic Carriers from a Large Brazilian Pedigree of 11778 Leber Hereditary Optic Neuropathy

Abstract

Luminance and chromatic spatial CS losses that affected all tested spatial frequencies, are reported in LHON asymptomatic carriers with the mtDNA 11778 mutation. No losses were found in the temporal CSF. An intriguing finding is that the blue system is substantially spared in this LHON family. These represent subclinical visual impairments in otherwise asymptomatic LHON carriers.