The structure of roxburghilin, a bis-amide of 2-aminopyrrolidine from the leaves of Aglaia roxburghiana(meliaceae)

Abstract

Roxburghilin, a bis-amide from the leaves of Aglaia roxburghiana(Meliaceae) has been shown to be N-cinnamoyl-2-(2-methylbutanoylamino)pyrrolidine (1) by a combination of chemical and spectroscopic evidence, and by synthesis of the corresponding dihydro-derivative (4) from L-proline.