ColonialDifferentiation in <i>Streptomyces</i> <i>coelicolor</i> Depends on Translation of a SpecificCodon within the <i>adpA</i> Gene

Abstract

We identified adpA as an araC-like regulatory gene needed for colonial morphogenesis in Streptomyces coelicolor and showed that its activity depended on a unique TTA triplet corresponding to the leucyl-tRNA gene (bldA). These findings partially explained the dependence of aerial mycelium formation on a rare tRNA that is postulated to have developmental control functions.