The <i>Interleukin‐1 RN</i> Polymorphism and <i>Helicobacter pylori</i> Infection in the Development of Duodenal Ulcer

Abstract

This work is the first to verify IL-1RN*2 as an independent factor that governs the development of duodenal ulcers. Our data indicate that H. pylori infection and IL-1RN*2 synergistically determine susceptibility to duodenal ulcer. The blood group phenotype is possibly a crucial determinant for the outcome of the impact of an interleukin-1 locus polymorphism on H. pylori-infected individuals.