Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

G L Wang, Bing‐Hua Jiang, E A Rue, +1

Proceedings of the National Academy of Sciences

GeneticsMolecular BiologyHif-1 SubunitsRedox BiologyCellular Physiology +19

Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

Peter Carmeliet, Yuval Dor, Jean-Marc Herbert, +13

Nature

Tumor BiologyHypoxia-mediated ApoptosisRedox RegulatorApoptosisHypoxia (Medicine) +13

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.

Gregg L. Semenza, G.L. Wang

Molecular and Cellular Biology

Protein Synthesis BindsGeneticsRedox BiologyOxidative StressTranscriptional Regulation +14

Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

Peter C. Brooks, Anthony M.P. Montgomery, Mauricio Rosenfeld, +4

Cell

Tumor RegressionAngiogenesisAngiogenic Blood VesselsIntegrin αVβ3Cell Signaling +10

Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases.

Hua Zhong, Angelo M. De Marzo, Erik Laughner, +7

PubMed

PathologyCancer BiologyTumor BiologyTumor InvasionIncreased Glycolysis +17

The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

Katherine Louise Talks, Helen Turley, Kevin C. Gatter, +4

American Journal Of Pathology

InflammationTumor BiologyHypoxia-inducible Factors Hif-1αTumor-associated MacrophagesNormal Human Tissues +10

A Nuclear Factor Induced by Hypoxia via De Novo Protein Synthesis Binds to the Human Erythropoietin Gene Enhancer at a Site Required for Transcriptional Activation

Gregg L. Semenza, Guang L. Wang

Molecular and Cellular Biology

GeneticsNuclear Factor InducedRedox BiologyOxidative StressTranscriptional Regulation +14

Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth.

Heather E. Ryan, M Poloni, William McNulty, +4

PubMed

Solid Tumor GrowthOncologyAngiogenesisHypoxia-inducible Factor-1alphaMedicine +12

Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer.

Peter Birner, Monika Schindl, Andreas Obermair, +3

PubMed

Hif-1alpha ExpressionOncologyCervical CancerHypoxia-inducible Factor 1AlphaMedicine +12

Expression of hypoxia-inducible factor 1? in brain tumors

David Zagzag, Hua Zhong, Joanne M. Scalzitti, +3

Cancer