VFDB: a reference database for bacterial virulence factors

TLDR

Bacterial pathogens pose a major global health threat, and recent molecular studies have expanded understanding of their pathogenic mechanisms. VFDB was created to provide researchers with a centralized, up‑to‑date resource of bacterial virulence factors. VFDB offers genus‑based browsing, keyword search, and a BLAST tool, serving as a unified platform to store, retrieve, and update virulence factor data. The database is comprehensive and user‑friendly.

Abstract

Bacterial pathogens continue to impose a major threat to public health worldwide in the 21st century. Intensified studies on bacterial pathogenesis have greatly expanded our knowledge about the mechanisms of the disease processes at the molecular level over the last decades. To facilitate future research, it becomes necessary to form a database collectively presenting the virulence factors (VFs) of various medical significant bacterial pathogens. The aim of virulence factor database (VFDB) ( http://www.mgc.ac.cn/VFs/ ) is to provide such a source for scientists to rapidly access to current knowledge about VFs from various bacterial pathogens. VFDB is comprehensive and user-friendly. One can search VFDB by browsing each genus or by typing keywords. Furthermore, a BLAST search tool against all known VF-related genes is also available. VFDB provides a unified gateway to store, search, retrieve and update information about VFs from various bacterial pathogens.