Discovery of Chromone‐Based Inhibitors of the Transcription Factor STAT5

Abstract

Obstacles overcome: Gene-specific transcription factors are emerging therapeutic targets, but their direct inhibition is considered to be difficult because of the absence of enzymatic activities. This manuscript describes the discovery of chromone-based inhibitors of the protein–protein interactions required for activity of the transcription factor STAT5, a therapeutic target for the treatment of human cancers. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2268/2008/z700701_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.