Palladium‐Catalyzed Oxidative CC Bond Cleavage of α‐Hydroxyketones: Application to CH Acylation of Azoarenes and Synthesis of a Liver(X) Receptor Agonist

Abstract

Abstract Palladium‐catalyzed oxidative CC cleavage of α‐hydroxyketones and 2‐aryl acetophenones in the presence of tert ‐butyl hydrogen peroxide (TBHP) generates an acyl moiety, which promotes subsequent regioselective CH acylation producing a series of ortho‐ acyl substituted symmetrical and unsymmetrical azoarenes. This protocol is successfully used for the synthesis of liver (X) receptor agonist.