Asymmetric Hydrogenation of Ketones Catalyzed by Ru^II–bicp Complexes

Abstract

Variations on a theme: A RuII–bicp complex used in combination with an achiral 2-(alkylthio)amine ligand (or achiral 1,2-diamine ligand) is an efficient catalyst for the highly enantioselective hydrogenation of a variety of ketones (see scheme). In some cases simply changing the amine ligand and/or the solvent leads to opposite enantioselectivity. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2004/z53441_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.