Prevalence and Characteristics of <i>MUTYH</i> -Associated Polyposis in Patients with Multiple Adenomatous and Serrated Polyps

Abstract

We observed a low frequency of MUTYH mutations among patients with multiple adenomatous and serrated polyps. The MAP phenotype frequently included patients with serrated polyps, especially when G396D mutation was involved. Our results show that somatic molecular markers of polyps can be useful in identifying MAP cases and support the need for the complete MUTYH gene analysis only in patients heterozygous for recurrent variants.