Concepedia

Efficacy and safety of entacapone in Parkinson's disease patients with suboptimal Levodopa response: a 6-month randomized placebo-controlled double-blind study in Germany and Austria (Celomen study)

Werner Poewe, Günther Deuschl, A. Gordin, E.‐R. Kultalahti, M. Leinonen

Acta Neurologica Scandinavica · 2002 · 208 citations · 18 references

DOI

Abstract

Entacapone is an effective and safe levodopa extender and enhancer, improving the symptomatic efficacy of levodopa in PD and adding to the patients' benefit.

References

18

SUCCESS AND PROBLEMS OF LONG-TERM LEVODOPA THERAPY IN PARKINSON'S DISEASE

C. D. Marsden, J. D. Parkes · The Lancet · 1977 · 589 citations

, , +5

Entacapone enhances the response to levodopa in parkinsonian patients with motor fluctuations

U. K. Rinne, Jan Larsen, Å Sidén et al. · Neurology · 1998 · 324 citations

Entacapone improves motor fluctuations in levodopa‐ treated Parkinson's disease patients

Annals of Neurology · 1997 · 306 citations

Effect of peripheral catechol‐O‐methyltransferase inhibition on the pharmacokinetics and pharmacodynamics of levodopa in parkinsonian patients

John G. Nutt, William R. Woodward, R. M. Beckner et al. · Neurology · 1994 · 246 citations

The Application of the Principle of Intention–to–Treat to the Analysis of Clinical Trials

Dennis B. Gillings, Gary G. Koch · Drug Information Journal · 1991 · 229 citations

, , +7