2003 Wolff Award: Possible Parasympathetic Contributions to Peripheral and Central Sensitization During Migraine

Abstract

These findings suggest that cranial parasympathetic outflow contributes to migraine pain by activating or sensitizing (or both) intracranial nociceptors, and that these events induce parasympathetically independent allodynia by sensitizing the central nociceptive neurons in the spinal trigeminal nucleus.