In Vitro Activities of Voriconazole, Itraconazole, and Terbinafine Alone or in Combination against <i>Pythium insidiosum</i> Isolates from Brazil

Abstract

We evaluated the in vitro activities of voriconazole, itraconazole, and terbinafine against 30 clinical isolates of Pythium insidiosum using a checkerboard macrodilution method. The combined activity of terbinafine plus itraconazole or plus voriconazole was synergic against 17% of the strains. Antagonism was not observed.