Pseudo Pelger-Huet anomaly in myelodysplastic syndrome: hyposegmented or apoptotic neutrophil?

Abstract

prognostic feature in MDS that is associated with an imminent risk for leukemic transformation. We do not, however, base a diagnosis of ALIP on bone marrow clot sections alone. All myeloblast clusters identified in marrow clot sections were confirmed by trephine biopsy prior to immunohistochemical staining. Our use of bone marrow clot sections to examine VEGF and receptor expression was predicated on the superior staining characteristics of bone marrow clot sections as compared to cores under the conditions used for staining in this study. Nevertheless, Mangi's letter now prompts us to include a figure showing VEGF expression in ALIP in a bone marrow trephine biopsy. Although the level of staining is not as optimal as that observed in the clot sections provided in the original manuscript, VEGF expression is clearly demonstrated (Figure