Concepedia

Regional Lung Deposition and Bronchodilator Response as a Function of β <sub>2</sub> -Agonist Particle Size

Omar S. Usmani, Martyn F. Biddiscombe, Peter J. Barnes

American Journal of Respiratory and Critical Care Medicine · 2005 · 574 citations · 45 references

DOI

Abstract

Regional targeting of inhaled beta2-agonist to the proximal airways is more important than distal alveolar deposition for bronchodilation. Altering intrapulmonary deposition through aerosol particle size can appreciably enhance inhaled drug therapy and may have implications for developing future inhaled treatments.

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