Concepedia

A Specific Role for eNOS-Derived Reactive Oxygen Species in Atherosclerosis Progression

Tomofumi Takaya, Ken‐ichi Hirata, Tomoya Yamashita, Masakazu Shinohara, Naoto Sasaki, Nobutaka Inoue, Toyotaka Yada, Masami Goto, Akiko Fukatsu, Toshio Hayashi,

Arteriosclerosis Thrombosis and Vascular Biology · 2007 · 95 citations · 26 references

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Abstract

In contrast to vitamin C treatment, augmenting BH4 levels in the endothelium by GCH overexpression reduced the accelerated atherosclerotic lesion formation in ApoE-KO/eNOS-Tg mice, associated with a reduction of superoxide production from uncoupled eNOS.

References

26

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Ulf Landmesser, Sergey Dikalov, S. Russ Price et al. · Journal of Clinical Investigation · 2003 · 1.5K citations · Full text

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Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

Ulf Landmesser, Sergey Dikalov, S. Russ Price et al. · Journal of Clinical Investigation · 2003 · 1.4K citations · Full text

Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus.

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Accelerated Atherosclerosis, Aortic Aneurysm Formation, and Ischemic Heart Disease in Apolipoprotein E/Endothelial Nitric Oxide Synthase Double-Knockout Mice

Peter Kuhlencordt, Robert Gyurko, Fred Han et al. · Circulation · 2001 · 620 citations