Isoprostanes: Free Radical–Generated Prostaglandins With Constrictor Effects on Cerebral Arterioles

Abstract

Isoprostanes are potent constrictors of cerebral arterioles and appear to act at a receptor that is similar to the thromboxane A2/prostaglandin H2 receptor. Isoprostanes may play a role in the reduction of cerebral blood flow that occurs after brain injury and subsequent oxygen radical production.