Ornithocholanic Acids--Abnormal Conjugates of Bile Acids.

Abstract

L-ornithine conjugate of the 2 cholanic acids of the immature and the 3 cholanic acids of the adult guinea pig have been identified in bile following injection of a toxic, C14-labeled capsular polysaccharide of Klebsiella pneumoniae. Preferential conjugation of L-ornithine with cholic acid by rat and guinea pig liver has been demonstrated in vitro.