Activation of the Melanocortin-4 Receptor Mobilizes Intracellular Free Calcium in Immortalized Hypothalamic Neurons

Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice

Dennis Huszar, Catherine Lynch, Victoria Fairchild-Huntress et al. · Cell · 1997 · 3K citations · Full text

Obesity, Metabolic Syndrome, Energy Homeostasis +12

Congenital leptin deficiency is associated with severe early-onset obesity in humans

I. Sadaf Farooqi, Jonathan P. Whitehead, Maria A. Soos et al. · Nature · 1997 · 2.9K citations · Full text

Obesity, Metabolic Syndrome, Nutrition +10

Excess Deaths Associated With Underweight, Overweight, and Obesity

Katherine M. Flegal · JAMA · 2005 · 2.8K citations

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

Karine Clément, Christian Vaisse, Najiba Lahlou et al. · Nature · 1998 · 2.4K citations

Obesity, Metabolic Syndrome, Endocrine Mechanism +10

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

Wei Fan, Bruce A. Boston, Robert A. Kesterson et al. · Nature · 1997 · 1.9K citations

Obesity, Metabolic Syndrome, Energy Homeostasis +12