Electrocardiographic Characteristics and <i>SCN5A</i> Mutations in Idiopathic Ventricular Fibrillation Associated With Early Repolarization

Abstract

We found reductions in heart rate and cardiac conduction and loss-of-function mutations in SCN5A in patients with idiopathic ventricular fibrillation associated with early repolarization. These findings support the hypothesis that decreased sodium current enhances ventricular fibrillation susceptibility.