A comparison of measures of disproportionality for signal detection on adverse drug reaction spontaneous reporting database of Guangdong province in China

Abstract

The ROR, PRR and BCPNN measures used are broadly comparable when three or more cases per combination have been collected. The MHRA measure is comparable to the BCPNN when seven or less case per combination have been collected for 'drug-ADR', 'drug category-ADR', 'drug-ADR category' combinations based on the Guangdong database, and the MHRA is unsuitable for detecting signals from 'drug category-ADR category' combinations based on the Guangdong database because of its low sensitivity.