Virus-induced Diabetes Mellitus. XXV. Difference in the RNA Fingerprints of Diabetogenic and Non-diabetogenic Variants of Encephalomyocarditis Virus

Abstract

SUMMARY The genomes of diabetogenic and non-diabetogenic variants of encephalomyocarditis virus were analysed by nucleic acid hybridization and RNA fingerprinting. Hybridization and thermal elution profiles failed to show any difference between the RNAs of the two variants, whereas fingerprinting of the T1-digested RNAs revealed at least one oligonucleotide, 20 to 25 nucleotides long, missing in the non-diabetogenic variant.