Multilocus Binding Increases the Relaxivity of Protein‐Bound MRI Contrast Agents

Abstract

Spinning around: The sensitivity of MRI contrast agents can be increased through multilocus binding. This restricts the internal motion and therefore increases the relaxivity of a bound protein multimer (see picture; A) relative to a single binding group (B), whose flexibility and internal motion limits the relaxivity gain. Protein-targeting groups (TG) can be used to anchor the multimer. Supporting information (synthesis of 1, 2, and 3) for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2005/z502245_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.