Magnetic-resonance imaging for kinetic analysis of permeability changes during focused ultrasound-induced blood–brain barrier opening and brain drug delivery

Measurement of the blood‐brain barrier permeability and leakage space using dynamic MR imaging. 1. Fundamental concepts

Paul S. Tofts, Allan G. Kermode · Magnetic Resonance in Medicine · 1991 · 1.5K citations

Medicine, Neuroscience, Radiology +17

Noninvasive MR Imaging–guided Focal Opening of the Blood-Brain Barrier in Rabbits

Kullervo Hynynen, Nathan McDannold, Natalia Vykhodtseva et al. · Radiology · 2001 · 1.5K citations

Medicine, Biomedical Engineering, Radiology +17

Local and reversible blood–brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications

Kullervo Hynynen, Nathan McDannold, Nickolai Sheikov et al. · NeuroImage · 2004 · 686 citations

Engineering, Biomedical Engineering, Neuroscience +12

Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI‐guided focused ultrasound

Lisa H. Treat, Nathan McDannold, Natalia Vykhodtseva et al. · International Journal of Cancer · 2007 · 548 citations

Pharmacy, Pharmaceutics, Pharmacology +17

Effect of Focused Ultrasound Applied With an Ultrasound Contrast Agent on the Tight Junctional Integrity of the Brain Microvascular Endothelium

Nickolai Sheikov, Nathan McDannold, Shipra Sharma et al. · Ultrasound in Medicine & Biology · 2008 · 495 citations · Full text

Veterinary Medicine, Bioengineering, Neuroscience +17