PROLONGED CARDIAC ALLOGRAFT SURVIVAL IN RATS SYSTEMICALLY INJECTED ADENOVIRAL VECTORS CONTAINING CTLA4IG-GENE1

Abstract

The adenovirous-mediated CTLA4Ig gene transfer into a recipient liver by systemic administration resulted in remarkable prolongation of cardiac allograft survival. Its action mechanisms may be mediated by inhibition of CD28-associated signal transduction, reduction of Th1-type cytokine production, and continuous expression of Th2-type cytokines in the activating lymphocytes.