Concepedia

Functional bioengineered corneal epithelial sheet grafts from corneal stem cells expanded ex vivo on a temperature-responsive cell culture surface

Kohji Nishida, Masayuki Yamato, Yasutaka Hayashida, Katsuhiko WATANABE, Naoyuki Maeda, Hitoshi Watanabe, Kazuaki Yamamoto, Shigeru Nagai, Akihiko Kikuchi, Yasuo Tano,

Transplantation · 2004 · 558 citations · 26 references

DOI

Abstract

Cell sheet engineering technology allows us to create intact, transplantable corneal epithelial cell sheets that retain stem cells from limbal stem cells expanded ex vivo. Our research indicates highly promising clinical capabilities for our bioengineered corneal epithelial sheet.

References

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Graziella Pellegrini, Elena Dellambra, Osvaldo Golisano et al. · Proceedings of the National Academy of Sciences · 2001 · 1.4K citations · Full text

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