Concepedia

Incorrect DNA methylation of the DAZL promoter CpG island associates with defective human sperm†

Paulo Navarro‐Costa, Paulo Nogueira, M. da G. da C. Carvalho, Fernanda Leal, Isabel Cordeiro, Carlos Calhaz–Jorge, João Gonçalves, Carlos E. Plancha

Human Reproduction · 2010 · 154 citations · 31 references

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Abstract

An association between disrupted DNA methylation of a key spermatogenesis gene and abnormal human sperm is described here for the first time. These results suggest that incorrect epigenetic marks in germline genes may be correlated with male gametogenic defects.

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