PnPP-19, a Synthetic and Nontoxic Peptide Designed from a <i>Phoneutria nigriventer</i> Toxin, Potentiates Erectile Function via NO/cGMP

Abstract

PnPP-19 potentiates erection in vivo and ex vivo via the nitric oxide/cyclic guanosine monophosphate pathway. It does not affect sodium channels or rat hearts and shows no toxicity and low immunogenicity. These findings make it a promising candidate as a novel drug in the therapy of erectile dysfunction.