Concepedia

Publication | Closed Access

Rapid detection of chromosomal aneuploidies in uncultured amniocytes by multiplex ligation-dependent probe amplification (MLPA)

DOI

64

Citations

21

References

2005

Year

Ron Hochstenbach, Judith Meijer, J. van de Brug, I. Vossebeld-Hoff, Renée S. Jansen, Rob B. van der Luijt, Richard J. Sinke, Godelieve C.M.L. Page‐Christiaens, Johannes Kristian Ploos van Amstel, Jennie M. Pater
Prenatal Diagnosis

Abstract

Sensitivity, specificity, and failure rate of MLPA were comparable to those of FISH and QF-PCR. Aneuploidy screening in uncultured amniocytes by MLPA is feasible in a clinical diagnostic setting, yielding an informative and rapid result in 98% of cases.

References

YearCitations

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