The Journals of Gerontology Series A · 2001 · 21 citations · 12 references
MedicineMolecular BiologyOncologyAgingCarcinogenesisMolecular OncologyBiological AgingCancer BiomarkersCellular AgingColorectal CancerOxidative StressOxidative Stress In CarcinogenesisAge-related Oxidative StressBiological Age BiomarkersColorectal Cancer BiomarkersColorectal Carcinogenesis PathophysiologyGastrointestinal PolypsOxidative Damage BiomarkersOxidative Dna LesionsOxidative Stress In Cancer
To clarify the role of oxidative stress in aging of colorectal tissue, we analyzed the 8-hydroxydeoxyguanosine (8-OH-dG) levels in colorectal biopsy samples from normal tissue of patients with either colorectal cancer (n = 15) or benign colorectal polyps (n = 40). An age-associated increase of 8-OH-dG was observed (p =.002), although the 8-OH-dG levels were not significantly different between the patients with cancer and those with polyps. These results suggest an increased level of 8-OH-dG formation in human colorectal tissue with age.
12