Macromolecular Chemistry and Physics · 2011 · 14 citations · 12 references
PharmacyMolecular PharmaceuticsPharmaceuticsDrug DeliveryNanomaterialsNanoparticle Drug DeliveryInorganic NanoparticlesNanomedicineNanoparticle Delivery SystemsNanoparticle FormulationsNanoparticle SynthesisPolymeric NanoparticlesBiodegradable Polymeric NanomaterialsBiodegradable Polymeric NanoparticlesCore-shell Polymeric NanoparticlesDrug Delivery PolymersPermeation MechanismPermeation PathwaysPolymer NanoparticlesPolymeric Nanoparticle Synthesis
Abstract Potentially biodegradable graft polymer core‐shell nanoparticles assembling by addition of metal ions intended to be used for radionuclide and drug delivery purposes are described. With Cu 2+ ions, the self‐assembly is slow (within minutes) with low efficiency. With Fe 3+ ions the nanoparticles are formed immediately and are of convenient size for passive tumor accumulation by the enhanced permeation and retention effect. Full in vitro degradation of these particles is achieved with deferoxamine as a model of in vivo transchelation capacity.
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