Acta Crystallographica Section E Structure Reports Online · 2011 · 29 citations · 3 references
Natural SciencesChemistryMedicinal ChemistryOrganic ChemistryStructural BiologySupramolecular ChemistryBiomolecular StructureHeterocyclic ChemistryHeterocyclic CompoundsMolecular StructureSecondary StructureBackbone ConformationEnvelope ConformationHelical ConformationHydrogen Bond GeometryPyridine Chemistry
The dihydro-pyridine ring in the title compound, C(25)H(31)NO(4), adopts an envelope conformation with the methine C atom representing the flap. The cyclo-hexenone rings also adopt envelope conformations with the C atoms bearing the methyl C atoms representing the flaps. The phenolic hy-droxy group forms an intra-molecular hydrogen bond to one of the two keto O atoms. The hy-droxy group of the N-bonded alkyl chain forms an inter-molecular hydrogen bond to the other keto O atom of an adjacent mol-ecule. The latter hydrogen bond leads to the formation of a helical chain running along the b axis.
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George M. Sheldrick · Acta Crystallographica Section A Foundations of Crystallography · 2007 · 87.4K citations · Full text