The periodontium of periodontitis patients contains citrullinated proteins which may play a role in <scp>ACPA</scp> (anti‐citrullinated protein antibody) formation

Abstract

Within the periodontal stroma, citrullination is an inflammation-depended process. In periodontal epithelium, citrullination is a physiological process. Additional citrullinated proteins are formed in periodontitis, apparently similar to those formed in RA-affected synovial tissue. Periodontitis induced citrullination may play a role in the aetiology of rheumatoid arthritis.