Attributable Mortality of Nosocomial Candidemia, Revisited

TLDR

The study matched 108 pairs of nosocomial candidemia patients with controls on age, sex, admission date, underlying disease, time at risk, and surgical procedures to compare outcomes. Nosocomial candidemia was associated with a 49% attributable mortality (95% CI 38–60%) and a 61% crude mortality versus 12% in matched controls, indicating a markedly higher risk than underlying disease alone.

Abstract

We reexamined the attributable mortality of nosocomial candidemia 15 years after a retrospective cohort study performed at our hospital demonstrated an attributable mortality of 38%. For all episodes of nosocomial candidemia between 1 July 1997 and 30 June 2001, we matched control patients with case patients by age, sex, date of hospital admission, underlying disease(s), length of time at risk, and surgical procedure(s). We analyzed 108 matched pairs. There were no statistically significant differences in age, sex, underlying disease(s), time at risk, surgical procedure, or vital signs at admission between cases and controls. The crude mortality among case patients was 61% (66 of 108 patients), compared with 12% (13 of 108) among control patients, for an attributable mortality of 49% (95% CI, 38%–60%). Nosocomial candidemia is still associated with an extremely high crude and attributable mortality—much higher than that expected from underlying disease alone.