Epidemiology and Infection · 2010 · 51 citations · 29 references
MedicineImmunologyInfectious DiseasesImmunizationImmunology Of Infectious DiseasesVaccinologyAdult ImmunizationImmunization PracticeInfant ImmunizationPediatric ImmunizationVaccinationVaccine-preventable DiseasesAge-specific SeroprevalenceMeasles-mumps-rubella VaccinationRubella VaccinationSex-specific SeroprevalenceTetanus-diphtheria VaccinationUniversal FreeVaccine Preventable InfectionsVaccine-preventable Disease Surveillance
Susceptibility to vaccine-preventable diseases in Belgium in 2006 was estimated from a serum survey. Immunoglobulins against measles, mumps, rubella (MMR) and diphtheria at all available ages (1-65 years), and against tetanus in >40-year-olds, were measured by ELISA. Age-standardized overall seronegativity for MMR was low (3·9%, 8·0%, 10·4%, respectively). However, the World Health Organization's targets for measles elimination were not met in 5- to 24-year-olds and about 1 in 7 women at childbearing age (15-39 years) were seronegative for rubella. In adults >40 years, tetanus immunity (87·2%, >0·16 IU/ml) largely exceeded diphtheria immunity (20-45%, >0·1 IU/ml). Despite free universal vaccination against MMR for more than 20 years and against diphtheria and tetanus for almost 60 years, our study revealed specific age groups remaining at risk for infection with these pathogens.
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Peter A. Briss, Laura J. Fehrs, Robert A. Parker et al. · The Journal of Infectious Diseases · 1994 · 166 citations