Stereoselective Total Synthesis of (+)‐Norrisolide

Abstract

In a convergent approach to the marine natural product (+)-norrisolide (1) the two bicyclic ring systems are coupled through the C9C10 bond to assemble the carbon framework in a late stage of the synthesis. Other highlights of the synthetic strategy include the formation of the unusual fused γ-lactone–γ-lactol motif of 1 through a sequence of oxidation reactions. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2004/z52868_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.