Pindolol Augmentation of Selective Serotonin Reuptake Inhibitors: PET Evidence That the Dose Used in Clinical Trials Is Too Low - Concepedia

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Pindolol Augmentation of Selective Serotonin Reuptake Inhibitors: PET Evidence That the Dose Used in Clinical Trials Is Too Low

77

Citations

6

References

2001

Year

Eugenii A. Rabiner, Zubin Bhagwagar, Roger N. Gunn, Peter A. Sargent, Christopher J. Bench, Philip J. Cowen, Paul M. Grasby

American Journal of Psychiatry

Abstract

The dose of pindolol used in clinical trials is suboptimal and may explain the inconsistent results. Therefore, a thorough test of pindolol's efficacy will necessitate doses higher than those used in present clinical trials.

References

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A Double-blind, Randomized, Placebo-Controlled Trial of Pindolol Augmentation in Depressive Patients Resistant to Serotonin Reuptake Inhibitors Víctor Pérez Archives of General Psychiatry	1999	155
Effect of Pindolol on Onset of Action of Paroxetine in the Treatment of Major Depression: Intermediate Analysis of a Double-Blind, Placebo-Controlled Trial Régis Bordet, Pierre Thomas, B Dupuis American Journal of Psychiatry	1998	126
β-blocker Binding to Human 5-HT1A Receptors in vivo and in vitro Implications for Antidepressant Therapy Eugenii A. Rabiner Neuropsychopharmacology Molecular PharmacologyAntidepressant TherapyPsychiatryHuman 5-Ht1a ReceptorsMedicine	2000	76
Pindolol occupancy of 5-HT1A receptors measured in vivo using small animal positron emission tomography with carbon-11 labeled WAY 100635 Ella Hirani, Jolanta Opacka‐Juffry, Roger N. Gunn, Synapse Pet-mriExperimental PharmacologyPositron Emission TomographySaturation Curve5-Ht1a Receptors	2000	50
Positron emission tomography study of pindolol occupancy of 5-HT1A receptors in humans: preliminary analyses Diana Martinez, Osama Mawlawi, Dah‐Ren Hwang, Nuclear Medicine and Biology Molecular PharmacologyPreliminary AnalysesMedicinePhysiology5-Ht1a Receptors	2000	22

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