Concepedia

Insulin Stabilizes Microvascular Endothelial Barrier Function via Phosphatidylinositol 3-Kinase/Akt-Mediated Rac1 Activation

Dursun Gündüz, Johannes Thom, Imran Hussain, Diego López-Guerra, Frauke V. Härtel, Ali Erdoğan, Mathias Grebe, Daniel Sedding, Hans Michael Piper, Harald Tillmanns,

Arteriosclerosis Thrombosis and Vascular Biology · 2010 · 45 citations · 36 references

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Abstract

Insulin stabilizes endothelial barrier via inactivation of the endothelial contractile machinery and enhancement of cell-cell adhesions. These effects are mediated via PI3K/Akt- and NO/cGMP-induced Rac1 activation.

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