Lewis Acid Catalyzed Intramolecular [3+2] Cross‐Cycloaddition of Donor–Acceptor Cyclopropanes with Carbonyls: A General Strategy for the Construction of Acetal[<i>n</i>.2.1] Skeletons

Abstract

Build a bridge: The first catalytic intramolecular [3+2] cycloaddition of monodonor-monoacceptor cyclopropanes (see scheme) provides a general and efficient strategy for construction of structurally diverse acetal[n.2.1] and 1,4-dioxygen-substituted cyclic skeletons, which are widely distributed in biologically important natural products.