Ni‐Catalyzed Cascade Formation of C(sp³)C(sp³) Bonds by Cyclization and Cross‐Coupling Reactions of Iodoalkanes with Alkyl Zinc Halides

Abstract

Two for the price of one: The formation of two C(sp3)C(sp3) bonds can be achieved in a single operation by sequential cyclization and cross-coupling of alkyl zinc bromides with iodoalkanes containing an alkene group (see scheme). The reaction is catalyzed by [Ni(py)4Cl2] in the presence of tridentate nitrogen ligands, shows a high functional-group compatibility, and seems to follow a radical mechanism. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z702528_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.