Publication | Closed Access
Protein Synthesis Directed by RNA Phage Messengers
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1966
Year
Nucleic Acid ChemistryAmino AcidsNatural SciencesProtein BiosynthesisNucleic Acid BiochemistryBiological SynthesisMolecular BiologyRna Phage MessengersGenetic CodeMolecular GeneticsRna TransportCell-free Amino AcidSystems BiologyMedicineGene ExpressionRna ProcessingProtein SynthesisMolecular Development
Even though the amino acids corresponding to most of the 64 nucleotide triplets are now known, several important aspects of the genetic code are not yet fully understood. In particular we need more knowledge about the “punctuation marks” of the code—for example, the signals necessary for the initiation or termination of polypeptide synthesis. One approach to the identification of these signals has been provided by the development of cell-free amino acid incorporating systems directed by naturally occurring messenger RNA molecules (Nathans, Notani, Schwartz, and Zinder, 1962; Ohtaka and Spiegelman, 1963; Nathans, 1965). Recently such systems, using RNA from the bacteriophage R17 and f2 as messenger, have told us that: