Concepedia

Intracellular Crystal Formation as a Mechanism of Cytotoxicity in Murine Pulmonary<i>Cryptococcus neoformans</i>Infection

Marta Feldmesser, Yvonne Kress, Arturo Casadevall

Infection and Immunity · 2001 · 42 citations · 29 references

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Concepts

Abstract

Rod-like crystalline structures formed during eosinophilic Cryptococcus neoformans pneumonia in C57BL/6 mice. Crystals were found associated with yeast cells and free in host cell cytoplasm. The crystals apparently formed because of the interaction of a host protein with the cryptococcal polysaccharide. Crystal formation likely contributes to pathogenesis by causing cellular damage.

References

29

Coupling of enzymes to proteins with glutaraldehyde

Stratis Avraméas · Immunochemistry · 1969 · 1.4K citations

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<i>Cryptococcus neoformans</i>Is a Facultative Intracellular Pathogen in Murine Pulmonary Infection

Marta Feldmesser, Yvonne Kress, Phyllis M. Novikoff et al. · Infection and Immunity · 2000 · 432 citations · Full text

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Characterization of a Murine Monoclonal Antibody to<i>Cryptococcus neoformans</i>Polysaccharide That Is a Candidate for Human Therapeutic Studies

Arturo Casadevall, Wendy Cleare, Marta Feldmesser et al. · Antimicrobial Agents and Chemotherapy · 1998 · 306 citations · Full text

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Antibodies Elicited by a Cryptococcus neoformans-Tetanus Toxoid Conjugate Vaccine Have the Same Specificity as Those Elicited in Infection

Arturo Casadevall, Jean Mukherjee, S J Devi et al. · The Journal of Infectious Diseases · 1992 · 220 citations

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Decreased virulence in stable, acapsular mutants ofCryptococcus neoformans

Robert A. Fromtling, H. Jean Shadomy, E S Jacobson · Mycopathologia · 1982 · 210 citations

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