Angewandte Chemie International Edition · 2008 · 104 citations · 23 references
Natural SciencesChemistryMedicinal ChemistryNatural Product BiosynthesisOrganic ChemistrySynthetic Medicinal ChemistryHeterocyclic ChemistryOrganic SynthesisCycloaddition ReactionsEnantioselective SynthesisRing-forming Reactions
Short and to the point: A formal synthesis of platensimycin has been accomplished by employing a carbonyl ylide [3+2] cycloaddition reaction (see scheme). This short and facile enantioselective synthesis of the pivotal tetracyclic precursor requires 11 steps and proceeds in 20 % overall yield from isopropyl cyanoacetate.
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Platensimycin is a selective FabF inhibitor with potent antibiotic properties
Jun Wang, S.M. Soisson, Katherine Young et al. · Nature · 2006 · 815 citations
Sheo B. Singh, Hiranthi Jayasuriya, John G. Ondeyka et al. · Journal of the American Chemical Society · 2006 · 231 citations
Total Synthesis of Platensimycin
K. C. Nicolaou, Ang Li, David J. Edmonds · Angewandte Chemie International Edition · 2006 · 189 citations