Concepedia

Elevated Cerebrospinal Fluid BACE1 Activity in Incipient Alzheimer Disease

Henrik Zetterberg, Ulf Andréasson, Oskar Hansson, Guoxin Wu, Sethu Sankaranarayanan, Malin E. Andersson, Peder Buchhave, Elisabet Londos, Robert M. Umek, Lennart Minthon,

Archives of Neurology · 2008 · 222 citations · 17 references

DOI

Abstract

Elevated BACE1 activity may contribute to the amyloidogenic process in sporadic AD and is associated with the intensity of axonal degeneration.

References

17

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Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study

Oskar Hansson, Henrik Zetterberg, Peder Buchhave et al. · The Lancet Neurology · 2006 · 1.7K citations · Full text

, , +10

Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Aβ <sub>42</sub> in humans

Anne M. Fagan, Mark A. Mintun, Robert H. Mach et al. · Annals of Neurology · 2005 · 1.2K citations