HMGB1-mediated autophagy promotes docetaxel resistance in human lung adenocarcinoma

Abstract

Our results demonstrated that HMGB1-regulated autophagy is a significant contributor to docetaxel resistance in LAD cells. Suppression of HMGB1 or limiting HMGB1 cytosolic translocation diminished autophagic protection in response to docetaxel in LAD cells.